Technical Note 125

DS-11 Advantages vs. NanoDrop™ 2000


The DeNovix® DS-11 Spectrophotometer is a compact, stand-alone instrument with clear advantages over leading competitors. The table below highlights some of the key features and advantages of the DS-11 versus the NanoDrop 2000.

 DeNovix DS-11AdvantageNanoDrop™ 2000Advantage
Fluorescence OptionYes - DS-11 FX and DS-11 FX+ (UV,Blue,Red,Green)None-
Warranty2 yearsI year-
Built-in ConnectivityYes, WiFi, Ethernet, USBUSB only-
SmartPath® Technology with Bridge Testing®*YesNo-
Protein PerformanceOutstandingOnly if sample column is formed properly*-
Bench Space Required20 x 33 cm50 x 22 cm
Instrument and Laptop
Microvolume Pathlength0.5 mm1.0 mm*-
Max ConcentrationdsDNA: 37,500 ng/μL
IgG: 547 mg/mL
dsDNA: 15,000 ng/μL
IgG: 219 mg/mL
Absorbance Range0.015 – 750 AU0.04 – 300 AU-
AutoRun FeatureYesNo-
Pathlength ControlPrecision screw driven by high resolution servo motorAdjustment screw driven by stepper motor-
Built-in ComputerYesNo, requires a PC-
Operating SystemAndroid™Windows® with version specific requirements-
Display Type7 " HD Color Touchscreen
Glove Compatible
SoftwarePreconfigured EasyApps®Standard Windows® Interface-
Color AvailabilityArctic White, Brazilian Blue,
Tungsten Silver, Fire Red
DesignModern lookDated-
Recalibration RequiredNoRecommended-

*An erroneous measurement can occur if an insufficient sample volume is pipetted for the microvolume measurement. In addition, many microvolume spectrophotometers, such as the NanoDrop 2000, can exhibit a phenomenon referred to as “unconditioning.” This is when the surface loses its hydrophobic property, and droplets spread out instead of beading up. The NanoDrop 2000 does not alert the user to a broken column and allows erroneous measurements to go undetected.  The DS-11 SmartPath® Technology detects if a sample does not fully bridge the path gap and automatically compensates for the issue in real time.


The next generation DeNovix DS-11 introduces new features to the microvolume spectrophotometer market, providing more confidence for a broader range of sample types and sample concentrations.

NanoDropTM and NanoDropTM One are registered trademarks of Thermo Fisher Scientific. 

Revised 19 Oct 2020