DeNovix DS-11 Series Compared with the Thermo Fisher NanoDrop™ One Spectrophotometer

The DeNovix DS-11 Series Spectrophotometer / Fluorometer and the Thermo Fisher NanoDrop™ One spectrophotometer are both used to perform fast quantification of nucleic acids and proteins. The DeNovix DS-11 Series provides superior limits of detection, the widest dynamic range, an easy-to-use interface and powerful networking features, which surpass the capabilities of the Thermo Fisher NanoDrop™ spectrophotometer. Here we will here we will outline the difference between the DeNovix DS-11 Series Spectrophotometer / Fluorometer and the Thermo Fisher NanoDrop™ One spectrophotometer.

NanoDrop Alternative DeNovix DS-11 Series Spectrophotometer / Fluorometer

The DS-11 was first introduced to the market in 2013 and was the first UV-Vis spectrophotometer in the world with a customized operating system, touchscreen control and network connection.

Over the years, DeNovix has expanded the instrument’s features and functionality by collaborating with the life science community. The DS-11 Series also includes a fluorometer mode option with higher sensitivity capabilities integrated into the system. The DS-11 FX+ is patented (US9442009) and offers outstanding limits of detection for fluorescence quantification (0.5 pg/μL dsDNA) and microvolume absorbance (0.75 – 37,500 ng/μL dsDNA).

In just one unit, labs can choose the integrated model that fits both current and future research needs with the combination of fluorescence detection, microvolume UV-Vis and cuvette UV-Vis. All DS-11 Series instruments come with a two-year factory warranty from DeNovix.

Table 1: DeNovix DS-11 Series Spectrophotometer / Fluorometer Comparison to Thermo Fisher NanoDrop™ One spectrophotometer

DS-11 Series
Thermo Fisher
NanoDrop™ Onec
Spectrophotometer / FluorometerSpectrophotometer
Fluorescence OptionYes - DS-11 FX and DS-11 FX+
(UV, Blue, Red, Green)
Dynamic Range (dsDNA)0.5 pg/μL* - 37500 ng/μL0.2 ng/μL - 27500 ng/μL
Protein PerformanceOutstandingOnly if sample column is properly formed
Microvolume Lower Detection LimitdsDNA: 0.75 ng/μL, BSA: 0.04 mg/mLdsDNA: 2.0 ng/μL, BSA: 0.06 mg/mL
Cuvette Lower Detection LimitdsDNA: 0.04 ng/μL, BSA: 0.002 mg/mLdsDNA: 0.2 ng/μL, BSA: 0.006 mg/mL
Max ConcentrationdsDNA: 37500 ng/μL, BSA: 1125 mg/mLdsDNA: 27500 ng/μL, BSA: 820 mg/mL
Wavelength Range190-840 nm190-850 nm
Absorbance Range0.015 - 750 A0.04 - 550 A
Wavelength Accuracy (Absorbance)0.5 nm1 nm
Absorbance Accuracy1.5% at 0.75 AU at 260nm3% at 0.97 AU at 302nm
Microvolume Pathlength0.5 to 0.02 mm1.0 to 0.03 mm
Pathlength VerificationSmartPath™ technology with Bridge Testing™ verificationAuto adjusting
Pathlength ControlPrecision screw driven by high resolution motorAdjustment screw driven by stepper motor
Contamination Alert SoftwareSmartQC™ contamination alertsYes
Data ExportNetwork Drives and Printers, Email, USB, Label PrintersUSB, Label Printer, Networks
NetworkingWi-Fi and EthernetWi-Fi not available in all areas, Ethernet
Color ChoicesArctic White, Brazilian Blue, Tungsten Silver, Fire RedNo
ErgonomicsOptimized screen and sample pedestal locationExtended reach required
* Using DeNovix dsDNA Ultra High Sensitivity Assay with fluorometer mode

See the full comparison of the DeNovix DS-11 Series Spectrophotometer / Fluorometer vs. the Thermo Fisher NanoDrop™ One spectrophotometer. Read the full technical note here.


NanoDrop™ and NanoDrop™ One are registered trademarks of Thermo Fisher Scientific and its subsidiaries and are used for identification and references purposes only. DeNovix, DeNovix products and this website are not endorsed by Thermo Fisher Scientific. DeNovix fluorometer products are provided under an intellectual property license from Life Technologies Corporation. See