DS-11 Series Spectrophotometer / Fluorometer

Award Winning Performance

DeNovix takes spectrophotometry to a whole new level of performance with the DS-11 Series. This easy-to-use, compact instrument delivers full spectrum UV-Vis analysis and fluorescence capability making it ideal for rapid nucleic acid and protein quantification. Our customers agree and have made the DeNovix DS-11 Series the 2017 and 2018 Reviewers’ Choice Product of the Year and the first life science instrument to be awarded the Platinum Seal of Quality by SelectScience based on scientist reviews for outstanding ease-of-use, performance, service and technical support.

Best in Class 1 uL Sensitivity and Highest Absorbance Capability

DS-11 Series Spectrophotometers set the industry standard for the lower detection limits of 0.5 -1.0 uL UV-Vis sample analysis. Detect to 0.75 ng/uL dsDNA, 0.60 ng/uL RNA or 0.04 mg/mL BSA.  The DS-11 can measure samples with absorbance values as high as 750 absorbance units (at a 1 cm equivalent path length). This translates into 1125 mg/ml of BSA protein or 37500 ng/uL of dsDNA. This ultra high absorbance capability is achieved by using a remarkably small pathlength enabled by our SmartPath® Technology.

 

Easy to Learn. Fast to Use.

The DS-11 Series instruments feature the most powerful and intuitive software of its type. EasyApps® software is designed by life scientists and combines with a breakthrough Android™ touchscreen interface to ensure error-free operation and sample to data in under 4 seconds. Every instrument is ready to go right out of the box – no PC set-up or software installation required.

Integrated Absorbance and Fluorescence for unmatched flexibility

The Only All-In-One Microvolume and Cuvette Absorbance with Fluorescence Design

With the DS-11 Series you can equip your lab for today’s quantification requirements and for future assay challenges. Combine the ease of use, wide dynamic range and contamination information of UV-Vis with the enhanced sensitivity and analyte-specific quantification of fluorescence for total sample quality control.

Absorbance and Fluorescence quantification are unique but complementary methods for assessing concentration and quality of biological samples. The multi-award winning DS-11 Series of 1 µL Spectrophotometers and Fluorometers provides the most sensitive and widest dynamic range for UV-Vis absorbance and fluorescence capability in one combined instrument.

1

Sensitivity

Extend the lower detection limit for low concentration samples. Quantify down to 0.5 pg/µL dsDNA
2

Specificity

Selectively quantify your sample in the presence of contaminants using DeNovix Fluorescence Quantification Assays
3

Total Sample QC

Combine Absorbance and Fluorescence measurements for specific quantification and reliable contamination detection.

Software Features

Nucleic Acid Quantification

  • Separate preconfigured apps for optimized workflow
  • Sample contaminant alerts
  • Preconfigured and user defined factors for ssDNA ensures appropriate concentration calculations
  • 260/280 and 260/230 ratios displayed
  • 11 Preconfigured dyes and fluorophores for Microarray
  • Option to add an unlimited number of new dyes for quick recall in Microarray
nucleic acid quantification software icons

Protein Quantification

  •   Preconfigured and user defined protein types for A280 and Labeled Proteins
  •   Preconfigured Peptide app for easy peptide analysis at A205/215
  •   Quick addition of new user defined protein types for improved workflow
  •   Ultra short pathlength enables high absorbance capability: up to 750 mg/mL BSA
  •   11 Preconfigured dyes and fluorophores for Labeled Proteins
  •   Option to add an unlimited number of new dyes for quick recall in Labeled Proteins
  •   BCA, Bradford, Lowry and 660 nm colorimetric assays optimized for ease of use
  •   Quick save and recall of standard curves available
Protein Quantification Software Icons

UV-Vis and Custom Apps

  •   Simple but powerful apps enable measurement of more than just nucleic acids and proteins
  •   Full spectrum analysis (190 – 840 nm)
  •   Broad absorbance range for highly concentrated samples (up to 750 A, 1 cm equivalent)
  •   Add new user-defined standard curve methods
  •   Add custom formulas to eliminate downstream calculations
  •   Add kinetics methods (DS-11+/DS-11FX+ models)
UV-Vis quantification Software icons

Fluorescence Quantification

  •   Preconfigured commonly used Qubit®, Quant-itTM and Qunatifluor® assays
  •   Easy configuration of additional assays
  •   Single or multi-replicate standard curve options
  •   User control of  line fit, trend line analysis, subtraction of blank
  •   User control of assay and reported sample concentration units
  •   Save and re-use curves and lists of standard concentrations

Custom Fluorescence Apps

  •   Add new standard curve based fluorescent assays (nucleic assay, protein or other)
  •   Basic Fluorometer app returns RFU values for many preconfigured and user-defined dyes/fluorophores
fluorescence quantification software icons

Kinetics and OD600

  •   DS-11+ model enables cuvette-based kinetics studies
  •   Full spectrum analysis (190 – 840 nm), with dual or single wavelength monitoring
  •   Built-in heater with temperature control between 37° and 45° C.
  •   Dual graphs enable absorbance vs time or absorbance vs. wavelength plots
  •   All kinetic data saved
  •   Estimated cell number calculator included in OD 600 app
kinetics UV-Vis measurements

User Accounts and Data Handling

  •   Password protected accounts available
  •   All data automatically saved & searchable by account, sample name & type, application and date
  •   Configurable reports easily accommodate LIMS and user preferred formats
  •   Print microfuge tube labels using a DeNovix supported printer
  •   Print reports to a networked printer or DeNovix supported label printer
  •   Export full data sets via email;  save to a network folder or USB thumb drive.
User account and data handling app

Exporting

Simply and securely connect the DS-11 to your network by Wifi or Ethernet to enable data exporting by email, or print reports to network or label printers. Each measurement is automatically saved to a large onboard memory enabling storage and retrieval of millions of samples. For labs requiring external data storage, network folder locations can be defined for each user account to automatically export and archive results.

Multiple Model and Color Choices

The DS-11 Series is available in 4 models with different combinations of
microvolume absorbance (M), cuvette absorbance (C) and Fluorescence (F):

DS-11 FX+ (M/C/F)
DS-11 FX (M/F)
DS-11+ (M/C)
DS-11 (M)

All models are available in multiple colors (red, white, blue and silver)

Specifications

Spectrophotometer Microvolume Mode (DS-11, DS-11+, DS-11 FX, DS-11 FX+)

Minimum Sample Size 0.5 µL
Pathlength 0.5 mm (auto ranging to 0.02 mm)
Light Source Pulsed Xenon flash lamp
Detector Type 2048 element CCD
Wavelength Range 190-840 nm
Wavelength Accuracy 0.5 nm
Wavelength Precision 0.14 nm
Spectral Resolution 1.5 nm (FWHM at Hg 253.7 nm)
Absorbance Precision 0.015 AU (1 cm) or 1%, whichever is greater
Absorbance Accuracy 1.5% at 0.75 AU at 260 nm
Absorbance Range 0.015 – 750 (1 cm equivalent)
Detection limit 0.04 mg/mL BSA; 0.75 ng/µL dsDNA
Maximum Concentration 1125 mg/mL BSA; 37500 ng/µL dsDNA
Lower Sample Surface Material of Construction 303 stainless steel and sapphire window
Upper Sample Surface Material of Construction 303 stainless steel and quartz fiber

Spectrophotometer Cuvette Mode (DS-11+, DS-11 FX+)

Beam height 8.5 mm
Heating 37-45 °C +/- 0.5 °C
Pathlength 10, 5, 2, 1, 0.5, 0.2, 0.125 mm
Absorbance Range 0.0008-1.5 AU (1 cm)
Detection Limit 0.002 mg/mL BSA; 0.04 ng/µL dsDNA (1 cm)
Maximum Concentration 75 ng/µL dsDNA (1 cm)

Fluorometer Mode (DS-11 FX, DS-11 FX+ and FX Module)

Light Sources UV LED (~375 nm), Blue LED (~470 nm),
Green LED (~525 nm), Red LED (~635 nm)
Excitation Filters UV: 361-389 nm, Blue: 442-497 nm,
Green: 490-558 nm, Red: 613-662 nm
Emission Filters 435-485 nm , 514-567 nm, 565-650 nm, 665-740 nm
Detectors Photodiode, detection range 300-1000 nm
Tube Type 0.5 mL Real Time thin-wall PCR tube (polypropylene)

Onboard Controller (No PC required)

Operating System Custom Android™ OS
CPU TI OMAP 1.5 GHz Dual Core ARM Processor
Display 1280 X 800 high definition color display
User Input Touch screen with swipe and pinch motion; glove compatible
Internal Storage 32GB flash drive
Connectivity 3 USB ports for printer, barcode reader and USB drive
Networking Ethernet and Wi-Fi

General

Colors Arctic White, Brazilian Blue, Fire Red, Tungsten Silver
Measurement Time for Spectrophotometry 2 seconds
Measurement Time for Fluorescence 2 seconds
Footprint 20 cm X 33 cm
Weight 2 kg
Operating Voltage 12 VDC
Operating Power Consumption 10 W; max 30 W
Approvals CE, UL/CSA, FCC and Japan CAB
Manufacture Location USA

FX Module: Upgrade to Fluorescence

Instantly add the power of fluorescence detection to any DeNovix DS-11, DS-11+ or DS-C Spectrophotometer. The FX Module uses the same fluorescence detection module as the DS-11 FX, DS-11 FX+ and QFX. Simply plug in this USB powered accessory and DeNovix fluorometric EasyApps® are immediately enabled. The easy-to-use apps are preconfigured for use with a wide choice of commercially available assays including those designed for Qubit® and QuantusTM platforms.

Absorbance and Fluorescence Quantification Infographic

Absorbance and Fluorescence quantification are unique but complementary methods for assessing concentration and quality of biological samples. The multi-award winning DS-11 Series of 1 µL Spectrophotometers and Fluorometers provides the most sensitive and widest dynamic range for UV-Vis absorbance and fluorescence capability in one combined instrument.

Selecting the appropriate quantification methods for biological samples is an important consideration in any quality control process. Download our infographic featuring comparisons of the key features of absorbance and fluorescence quantification and information on when each method should be applied or the results combined.

 

→ Download Infographic

Recent Posts

The DeNovix® dsDNA Ultra High Sensitivity Assay enables the accurate detection of purified double-stranded DNA (dsDNA) samples with a standard detection range of 0.5 pg – 300 pg total mass in 200 µL volumes and is compatible with a range of fluorometers and microplate readers.

Learn More…

Compare the DeNovix DS-11 FX+ with the NanoDrop™ One spectrophotometer to discover how DeNovix instruments are designed to be an all-in-one quantification system for your lab.

Compare the DeNovix DS-11 FX+ with the Qubit® Fluorometer.

View our comparison of absorbance and fluorescence quantification methods.

Additional Products

* Patent US9442009 – Apparatus and Method for Making Optical Measurements of Samples
NanoDrop ™ , NanoDrop ™ One, Quant-iT and Qubit® are registered trademarks of Thermo Fisher Scientific and its subsidiaries.
Quantifluor® is a registered trademark of Promega® Corporation.

For Research Use Only