The DS-11 Series of Spectrophotometer/Fluorometers from DeNovix and the NanoDrop™ One Spectrophotometer are both used to perform fast quantification of nucleic acids and proteins. The spectrophotometer/fluorometer range from DeNovix provides superior limits of detection, the widest dynamic range, an easy-to-use interface and powerful networking features, which surpass the capabilities of the NanoDrop™ Spectrophotometer. Here we will provide a comparison of the features of the DeNovix DS-11 FX Spectrophotometer/Fluorometers and the NanoDrop™ One Spectrophotometer.
Developed by the Creators of Microvolume UV-Vis
One of the founders, and core team members involved with NanoDrop Technologies Inc. is also a founding member of DeNovix. The DS-11 was first introduced to the market in 2013, and it was the first UV-Vis spectrophotometer in the world with a customized operating system, touchscreen control and be network-connected.
Over the years, DeNovix has expanded the instrument’s features and functionality by collaborating with the Life Science community. The DS-11 Series was created in 2015, when a fluorometer with high sensitivity was integrated into the system. The DS-11 FX+ is patented (US9442009) and offers outstanding limits of detection for fluorescence quantification (0.5 pg/μL dsDNA) and microvolume absorbance (0.75 – 37,500 ng/μL dsDNA).
In just one unit, labs can choose the integrated model that fits both current and future research needs with the combination of fluorescence detection, microvolume UV-Vis and cuvette UV-Vis. All DS-11 Series instruments come with a two-year factory warranty from DeNovix.Table 1: DS-11 Series Comparison to NanoDrop™ One
|DeNovix DS-11 Series||NanoDrop™ Onec|
|Fluorescence Option||Yes - DS-11 FX and DS-11 FX+ (UV,Blue,Red,Green)||None|
|Dynamic Range (dsDNA)||0.5 pg/μL* - 37500 ng/μL||0.2 ng/μL - 27500 ng/μL|
|Protein Performance||Outstanding||Only if sample column is properly formed|
|Microvolume Lower Detection Limit||dsDNA: 0.75 ng/μL, BSA: 0.04 mg/mL||dsDNA: 2.0 ng/μL, BSA: 0.06 mg/mL|
|Cuvette Lower Detection Limit||dsDNA: 0.04 ng/μL, BSA: 0.002 mg/mL||dsDNA: 0.2 ng/μL, BSA: 0.006 mg/mL|
|Max Concentration||dsDNA: 37500 ng/μL, BSA: 1125 mg/mL||dsDNA: 27500 ng/μL, BSA: 820 mg/mL|
|Wavelength Range||190-840 nm||190-850 nm|
|Absorbance Range||0.015 - 750 A||0.04 - 550 A|
|Wavelength Accuracy (Absorbance)||0.5 nm||1 nm|
|Absorbance Accuracy||1.5% at 0.75 AU at 260nm||3% at 0.97 AU at 302nm|
|Microvolume Pathlength||0.5 to 0.02 mm||1.0 to 0.03 mm|
|Pathlength Verification||SmartPath® Technology with BridgeTesting®||Auto adjusting|
|Pathlength Control||Precision screw driven by high resolution servo motor||Adjustment screw driven by stepper motor|
|Contamination Alert Software||SmartQC™ Sample Guidance||Yes|
|Data Export||Network Drives and Printers, Email, USB, Label Printers||USB, Label Printer, Networks|
|Networking||Wi-Fi and Ethernet||Wi-Fi not available in all areas, Ethernet|
|Color Choices||Arctic White, Brazilian Blue, Tungsten Silver, Fire Red||No|
|Ergonomics||Optimized screen and sample pedestal location||Extended reach required|
* Using DeNovix dsDNA Ultra High Sensitivity Assay
See the full comparison of the DS-11 Series Spectrophotometer/Fluorometers vs the NanoDrop™ One read the full technical note here.
NanoDrop ™ and NanoDrop ™ One are registered trademarks of Thermo Fisher Scientific and its subsidiaries.